Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2404870..2405387 Replicon chromosome
Accession NZ_CP125895
Organism Staphylococcus aureus strain CHAL5

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag QM342_RS11920 Protein ID WP_000113262.1
Coordinates 2404870..2405136 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag QM342_RS11925 Protein ID WP_000584499.1
Coordinates 2405136..2405387 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM342_RS11890 (2400293) 2400293..2400829 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
QM342_RS11895 (2401063) 2401063..2401887 - 825 WP_000594629.1 formate/nitrite transporter family protein -
QM342_RS11900 (2402103) 2402103..2402288 - 186 WP_000230293.1 hypothetical protein -
QM342_RS11905 (2402372) 2402372..2402839 - 468 WP_000153344.1 SRPBCC domain-containing protein -
QM342_RS11910 (2403025) 2403025..2404575 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
QM342_RS11915 (2404764) 2404764..2404835 - 72 Protein_2300 hypothetical protein -
QM342_RS11920 (2404870) 2404870..2405136 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
QM342_RS11925 (2405136) 2405136..2405387 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QM342_RS11930 (2405552) 2405552..2405632 - 81 WP_223197974.1 hypothetical protein -
QM342_RS11935 (2405660) 2405660..2406259 - 600 WP_000162810.1 DsbA family protein -
QM342_RS11940 (2406278) 2406278..2406640 - 363 WP_000819840.1 DUF4467 domain-containing protein -
QM342_RS11945 (2406895) 2406895..2408145 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
QM342_RS11950 (2408242) 2408242..2408973 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
QM342_RS11955 (2408970) 2408970..2409689 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T282425 WP_000113262.1 NZ_CP125895:c2405136-2404870 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT282425 WP_000584499.1 NZ_CP125895:c2405387-2405136 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References