Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1959739..1960492 Replicon chromosome
Accession NZ_CP125806
Organism Pasteurella multocida strain P030653/2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QM029_RS09485 Protein ID WP_015690952.1
Coordinates 1959739..1960065 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QM029_RS09490 Protein ID WP_015690953.1
Coordinates 1960166..1960492 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QM029_RS09460 (QM029_09460) 1955044..1955730 + 687 WP_015690949.1 hypothetical protein -
QM029_RS09465 (QM029_09465) 1955796..1957325 - 1530 WP_015690950.1 YifB family Mg chelatase-like AAA ATPase -
QM029_RS09470 (QM029_09470) 1957433..1958050 - 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
QM029_RS09475 (QM029_09475) 1958161..1959030 + 870 WP_015690951.1 VirK/YbjX family protein -
QM029_RS09480 (QM029_09480) 1959105..1959581 - 477 WP_005757697.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QM029_RS09485 (QM029_09485) 1959739..1960065 + 327 WP_015690952.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QM029_RS09490 (QM029_09490) 1960166..1960492 + 327 WP_015690953.1 HigA family addiction module antitoxin Antitoxin
QM029_RS09495 (QM029_09495) 1960546..1962066 - 1521 WP_015690954.1 surface lipoprotein assembly modifier -
QM029_RS09500 (QM029_09500) 1962125..1962727 - 603 WP_015690955.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
QM029_RS09505 (QM029_09505) 1962814..1963764 - 951 WP_015690956.1 hypothetical protein -
QM029_RS09510 (QM029_09510) 1964003..1965037 - 1035 WP_015690957.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12919.76 Da        Isoelectric Point: 9.6705

>T282406 WP_015690952.1 NZ_CP125806:1959739-1960065 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLNDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12403.49 Da        Isoelectric Point: 7.2034

>AT282406 WP_015690953.1 NZ_CP125806:1960166-1960492 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKILSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References