Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 207410..207664 Replicon plasmid pGYB02-2
Accession NZ_CP125736
Organism Klebsiella pneumoniae strain GYB02

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag QMW18_RS27365 Protein ID WP_001312851.1
Coordinates 207515..207664 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 207410..207471 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMW18_RS27330 (203062) 203062..203274 + 213 WP_005012601.1 hypothetical protein -
QMW18_RS27335 (203575) 203575..203664 - 90 Protein_247 IS1 family transposase -
QMW18_RS27340 (203719) 203719..204396 + 678 WP_001339397.1 IS66-like element accessory protein TnpA -
QMW18_RS27345 (204396) 204396..204743 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
QMW18_RS27350 (204763) 204763..206334 + 1572 WP_023149734.1 IS66-like element ISCro1 family transposase -
QMW18_RS27355 (206372) 206372..206988 - 617 Protein_251 IS1-like element IS1A family transposase -
QMW18_RS27360 (207089) 207089..207271 + 183 WP_000968309.1 hypothetical protein -
- (207410) 207410..207471 - 62 NuclAT_3 - Antitoxin
- (207410) 207410..207471 - 62 NuclAT_3 - Antitoxin
- (207410) 207410..207471 - 62 NuclAT_3 - Antitoxin
- (207410) 207410..207471 - 62 NuclAT_3 - Antitoxin
QMW18_RS27365 (207515) 207515..207664 + 150 WP_001312851.1 Hok/Gef family protein Toxin
QMW18_RS27370 (207948) 207948..208205 + 258 WP_000083833.1 replication regulatory protein RepA -
QMW18_RS27375 (208441) 208441..208515 + 75 WP_032336874.1 RepA leader peptide Tap -
QMW18_RS27380 (208508) 208508..208954 + 447 Protein_256 plasmid replication initiator RepA -
QMW18_RS27385 (208954) 208954..209568 - 615 Protein_257 VENN motif pre-toxin domain-containing protein -
QMW18_RS27390 (210275) 210275..211495 + 1221 WP_000410951.1 arginine deiminase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aadA5 / qacE / sul1 / blaNDM-5 / tet(B) / qepA1 / rmtB / blaTEM-1B / blaCTX-M-55 iucA / iucB / iucC / iucD / iutA 1..211607 211607


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-45)


Sequences


Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T282343 WP_001312851.1 NZ_CP125736:207515-207664 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp


Antitoxin


Download         Length: 62 bp

>AT282343 NZ_CP125736:c207471-207410 [Klebsiella pneumoniae]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829C8K5


Antitoxin

Download structure file

References