Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 207410..207664 | Replicon | plasmid pGYB02-2 |
Accession | NZ_CP125736 | ||
Organism | Klebsiella pneumoniae strain GYB02 |
Toxin (Protein)
Gene name | srnB | Uniprot ID | G9G1E3 |
Locus tag | QMW18_RS27365 | Protein ID | WP_001312851.1 |
Coordinates | 207515..207664 (+) | Length | 50 a.a. |
Antitoxin (RNA)
Gene name | srnC | ||
Locus tag | - | ||
Coordinates | 207410..207471 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QMW18_RS27330 (203062) | 203062..203274 | + | 213 | WP_005012601.1 | hypothetical protein | - |
QMW18_RS27335 (203575) | 203575..203664 | - | 90 | Protein_247 | IS1 family transposase | - |
QMW18_RS27340 (203719) | 203719..204396 | + | 678 | WP_001339397.1 | IS66-like element accessory protein TnpA | - |
QMW18_RS27345 (204396) | 204396..204743 | + | 348 | WP_000624622.1 | IS66 family insertion sequence element accessory protein TnpB | - |
QMW18_RS27350 (204763) | 204763..206334 | + | 1572 | WP_023149734.1 | IS66-like element ISCro1 family transposase | - |
QMW18_RS27355 (206372) | 206372..206988 | - | 617 | Protein_251 | IS1-like element IS1A family transposase | - |
QMW18_RS27360 (207089) | 207089..207271 | + | 183 | WP_000968309.1 | hypothetical protein | - |
- (207410) | 207410..207471 | - | 62 | NuclAT_3 | - | Antitoxin |
- (207410) | 207410..207471 | - | 62 | NuclAT_3 | - | Antitoxin |
- (207410) | 207410..207471 | - | 62 | NuclAT_3 | - | Antitoxin |
- (207410) | 207410..207471 | - | 62 | NuclAT_3 | - | Antitoxin |
QMW18_RS27365 (207515) | 207515..207664 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
QMW18_RS27370 (207948) | 207948..208205 | + | 258 | WP_000083833.1 | replication regulatory protein RepA | - |
QMW18_RS27375 (208441) | 208441..208515 | + | 75 | WP_032336874.1 | RepA leader peptide Tap | - |
QMW18_RS27380 (208508) | 208508..208954 | + | 447 | Protein_256 | plasmid replication initiator RepA | - |
QMW18_RS27385 (208954) | 208954..209568 | - | 615 | Protein_257 | VENN motif pre-toxin domain-containing protein | - |
QMW18_RS27390 (210275) | 210275..211495 | + | 1221 | WP_000410951.1 | arginine deiminase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | aadA5 / qacE / sul1 / blaNDM-5 / tet(B) / qepA1 / rmtB / blaTEM-1B / blaCTX-M-55 | iucA / iucB / iucC / iucD / iutA | 1..211607 | 211607 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T282343 WP_001312851.1 NZ_CP125736:207515-207664 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
Antitoxin
Download Length: 62 bp
>AT282343 NZ_CP125736:c207471-207410 [Klebsiella pneumoniae]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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