Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 331813..332399 Replicon chromosome
Accession NZ_CP125734
Organism Klebsiella pneumoniae strain GYB02

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag QMW18_RS01545 Protein ID WP_002920800.1
Coordinates 332031..332399 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag QMW18_RS01540 Protein ID WP_004174006.1
Coordinates 331813..332034 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMW18_RS01520 (QMW18_01520) 327970..328896 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QMW18_RS01525 (QMW18_01525) 328893..330170 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
QMW18_RS01530 (QMW18_01530) 330167..330934 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
QMW18_RS01535 (QMW18_01535) 330936..331649 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
QMW18_RS01540 (QMW18_01540) 331813..332034 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QMW18_RS01545 (QMW18_01545) 332031..332399 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QMW18_RS01550 (QMW18_01550) 332672..333988 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
QMW18_RS01555 (QMW18_01555) 334095..334982 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
QMW18_RS01560 (QMW18_01560) 334979..335824 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
QMW18_RS01565 (QMW18_01565) 335826..336896 + 1071 WP_017880090.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 328893..337633 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T282316 WP_002920800.1 NZ_CP125734:332031-332399 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT282316 WP_004174006.1 NZ_CP125734:331813-332034 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References