Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2960024..2960672 Replicon chromosome
Accession NZ_CP125620
Organism Mycobacterium tuberculosis strain BLR 4299 2019

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag O3Q54_RS13975 Protein ID WP_003899414.1
Coordinates 2960024..2960347 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag O3Q54_RS13980 Protein ID WP_003899415.1
Coordinates 2960427..2960672 (-) Length 82 a.a.

Genomic Context

O3Q54_RS13945O3Q54_RS13950O3Q54_RS13955O3Q54_RS14020O3Q54_RS14025O3Q54_RS13960O3Q54_RS13965O3Q54_RS13970O3Q54_RS13975O3Q54_RS13980O3Q54_RS13985O3Q54_RS13990O3Q54_RS13995O3Q54_RS14000O3Q54_RS14005O3Q54_RS14010O3Q54_RS14015
Location: 2955347..2956345 (999 bp)
Type: Others
Protein ID: WP_003900538.1
Location: 2956359..2956823 (465 bp)
Type: Others
Protein ID: WP_003900539.1
Location: 2956811..2957062 (252 bp)
Type: Others
Protein ID: WP_003908028.1
Location: 2964920..2965192 (273 bp)
Type: Others
Protein ID: WP_003900544.1
Location: 2965291..2965524 (234 bp)
Type: Others
Protein ID: WP_003413717.1
Location: 2957233..2958672 (1440 bp)
Type: Others
Protein ID: WP_003899411.1
Location: 2958680..2959213 (534 bp)
Type: Others
Protein ID: WP_003899412.1
Location: 2959366..2959857 (492 bp)
Type: Others
Protein ID: WP_003900541.1
Location: 2960024..2960347 (324 bp)
Type: Toxin
Protein ID: WP_003899414.1
Location: 2960427..2960672 (246 bp)
Type: Antitoxin
Protein ID: WP_003899415.1
Location: 2960669..2962096 (1428 bp)
Type: Others
Protein ID: WP_003899416.1
Location: 2962098..2962490 (393 bp)
Type: Others
Protein ID: WP_003899417.1
Location: 2962487..2962747 (261 bp)
Type: Others
Protein ID: WP_014585547.1
Location: 2962764..2963126 (363 bp)
Type: Others
Protein ID: WP_003900543.1
Location: 2963129..2964256 (1128 bp)
Type: Others
Protein ID: WP_003899420.1
Location: 2964401..2964628 (228 bp)
Type: Others
Protein ID: WP_003899421.1
Location: 2964625..2965014 (390 bp)
Type: Others
Protein ID: WP_003899422.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Q54_RS13945 (O3Q54_13945)2955347..2956345+999WP_003900538.1tyrosine-type recombinase/integrase-
O3Q54_RS13950 (O3Q54_13950)2956359..2956823+465WP_003900539.1ParB N-terminal domain-containing protein-
O3Q54_RS13955 (O3Q54_13955)2956811..2957062+252WP_003908028.1hypothetical protein-
O3Q54_RS13960 (O3Q54_13960)2957233..2958672-1440WP_003899411.1phage major capsid protein-
O3Q54_RS13965 (O3Q54_13965)2958680..2959213-534WP_003899412.1HK97 family phage prohead protease-
O3Q54_RS13970 (O3Q54_13970)2959366..2959857-492WP_003900541.1phage terminase small subunit P27 family-
O3Q54_RS13975 (O3Q54_13975)2960024..2960347-324WP_003899414.1type II toxin-antitoxin system toxinToxin
O3Q54_RS13980 (O3Q54_13980)2960427..2960672-246WP_003899415.1type II toxin-antitoxin system antitoxinAntitoxin
O3Q54_RS13985 (O3Q54_13985)2960669..2962096-1428WP_003899416.1DUF3631 domain-containing protein-
O3Q54_RS13990 (O3Q54_13990)2962098..2962490-393WP_003899417.1DUF2742 domain-containing protein-
O3Q54_RS13995 (O3Q54_13995)2962487..2962747-261WP_014585547.1helix-turn-helix domain-containing protein-
O3Q54_RS14000 (O3Q54_14000)2962764..2963126-363WP_003900543.1hypothetical protein-
O3Q54_RS14005 (O3Q54_14005)2963129..2964256-1128WP_003899420.1site-specific integrase-
O3Q54_RS14010 (O3Q54_14010)2964401..2964628-228WP_003899421.1hypothetical protein-
O3Q54_RS14015 (O3Q54_14015)2964625..2965014-390WP_003899422.1hypothetical protein-
O3Q54_RS14020 (O3Q54_14020)2964920..2965192+273WP_003900544.1hypothetical protein-
O3Q54_RS14025 (O3Q54_14025)2965291..2965524+234WP_003413717.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--2955347..29642568909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T282209 WP_003899414.1 NZ_CP125620:c2960347-2960024 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT282209 WP_003899415.1 NZ_CP125620:c2960672-2960427 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A045IHC4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A806JR81

References