28219

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 67476..68827 Replicon chromosome
Accession NC_018525
Organism Pectobacterium carotovorum subsp. carotovorum PCC21

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag PCC21_RS00290 Protein ID WP_014913672.1
Coordinates 67476..68516 (-) Length 347 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag PCC21_RS00295 Protein ID WP_014913673.1
Coordinates 68513..68827 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCC21_RS00260 62582..63934 + 1353 WP_014913667.1 glutathione-disulfide reductase -
PCC21_RS00265 64053..64341 - 289 Protein_51 type II toxin-antitoxin system RelE/ParE family toxin -
PCC21_RS00270 64338..64589 - 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PCC21_RS00275 64844..65749 + 906 WP_043901780.1 siderophore-interacting protein -
PCC21_RS00280 65783..66538 - 756 WP_014913670.1 thiol:disulfide interchange protein DsbG -
PCC21_RS00285 66793..67416 + 624 WP_014913671.1 LysE family translocator -
PCC21_RS00290 67476..68516 - 1041 WP_014913672.1 HipA domain-containing protein Toxin
PCC21_RS00295 68513..68827 - 315 WP_014913673.1 HipA N-terminal domain-containing protein Antitoxin
PCC21_RS00300 68812..69138 - 327 WP_014913674.1 helix-turn-helix domain-containing protein -
PCC21_RS00305 69301..70173 - 873 WP_014913675.1 LysR family transcriptional regulator -
PCC21_RS00310 70273..70785 + 513 WP_164671261.1 phenolic acid decarboxylase -
PCC21_RS00315 70842..71975 - 1134 WP_014913677.1 alkylhydroperoxidase domain protein -
PCC21_RS00320 71972..73006 - 1035 WP_014913678.1 putative FMN-dependent luciferase-like monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(57-307)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 347 a.a.        Molecular weight: 39539.53 Da        Isoelectric Point: 6.5556

>T28219 WP_014913672.1 NC_018525:c68516-67476 [Pectobacterium carotovorum subsp. carotovorum PCC21]
MTRCRILLTPLTHEEEIATGYSRKGLKHLAGKMHTSPALRFTRQQFMHDLPQAQKGMSISGYQPKIQLVLEEQAFTVVDH
QGLYILKPSPIEFPHLAENEHATMTLMARLGFAVPPHGLLRFKPEQADDEPEFAFVIKRFDRDEKTGHPIHQEQLDGAMG
IGEKFGKTHTDGRQYVSYERLALFLSKHVNDNIAFKIDLFRRIAYAYMLGNNDMHLRNFGLMHLRSGQLMLAPIYDFVSV
APYPTYFSSCFMALPLLIQEEGDEALAPGFETAYGEYLGMDFILFGQRIGLSENLTKKLLADLTKEAECVETTYRDSFMP
ADAIETTLRCYRHRLNLMSILDAERI

Download         Length: 1041 bp

>T28219 NC_018525:c68516-67476 [Pectobacterium carotovorum subsp. carotovorum PCC21]
ATGACAAGATGTCGAATTTTGCTGACACCGCTAACACACGAAGAAGAAATTGCCACAGGCTATAGCCGTAAAGGGTTGAA
GCATCTGGCGGGGAAAATGCACACTTCCCCAGCCTTACGTTTCACCCGCCAGCAATTTATGCACGACCTGCCACAAGCAC
AGAAAGGCATGAGTATCTCTGGCTATCAGCCCAAAATTCAGTTGGTATTAGAAGAACAGGCGTTTACCGTCGTTGATCAT
CAAGGGCTATACATCCTCAAACCCTCTCCGATTGAATTTCCCCATTTGGCAGAAAATGAACATGCCACGATGACGCTAAT
GGCACGTCTGGGATTTGCCGTTCCACCACACGGGTTACTCCGTTTTAAACCGGAACAGGCGGATGACGAACCTGAGTTCG
CTTTCGTTATTAAGCGCTTCGACCGCGACGAAAAAACGGGTCACCCTATCCATCAGGAACAGTTGGACGGGGCGATGGGG
ATCGGTGAAAAATTCGGAAAAACACATACAGATGGCAGACAATACGTCAGTTATGAGCGGTTGGCTTTATTCCTTAGCAA
ACACGTTAATGACAATATCGCCTTCAAAATAGATCTATTTCGCCGCATCGCTTACGCCTACATGTTGGGTAACAACGACA
TGCACCTGCGTAATTTTGGGCTGATGCATTTGCGCTCAGGCCAATTAATGCTGGCCCCTATTTATGACTTTGTTTCCGTC
GCCCCCTATCCCACCTATTTTTCTTCCTGTTTCATGGCATTGCCGCTGCTGATTCAAGAAGAGGGGGATGAGGCACTCGC
GCCAGGATTTGAAACCGCATACGGAGAATATCTTGGTATGGATTTCATTCTGTTCGGACAGCGTATCGGGCTGAGTGAAA
ACCTGACCAAAAAGCTACTGGCAGACCTCACCAAAGAAGCTGAATGCGTTGAAACAACCTATCGGGATTCCTTTATGCCT
GCGGATGCTATTGAGACAACGCTGCGGTGCTATCGACACCGCCTGAATCTTATGAGCATTCTAGATGCAGAACGGATTTA
G

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11914.73 Da        Isoelectric Point: 9.8041

>AT28219 WP_014913673.1 NC_018525:c68827-68513 [Pectobacterium carotovorum subsp. carotovorum PCC21]
MRRQVKVYLYGVHIGQLSQDDKGYLFEYKKSYIGPPLSLSLPIQTGTFRSRTLPPYFSSLAPEGWLRRQYSQLQHLDEKD
LFGILIQNGKNLIGAVQLIAEDKA

Download         Length: 315 bp

>AT28219 NC_018525:c68827-68513 [Pectobacterium carotovorum subsp. carotovorum PCC21]
ATGCGCCGTCAAGTAAAGGTCTATCTTTACGGTGTCCACATCGGCCAGCTAAGTCAGGACGATAAAGGCTATTTGTTTGA
ATATAAAAAGTCCTACATCGGCCCGCCATTATCACTAAGCCTACCGATACAGACCGGAACATTTCGCAGCAGGACATTAC
CGCCTTATTTTTCCTCGTTAGCTCCCGAAGGCTGGCTCCGGCGGCAGTACAGCCAGCTTCAGCATCTGGATGAGAAGGAT
TTATTTGGCATCCTCATTCAAAATGGTAAGAACCTGATCGGTGCCGTGCAACTGATCGCGGAGGATAAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References