Detailed information of TA system TA028218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2091008..2091711
• Replicon: chromosome
• Accession: NC_018524
• Organism: Nocardiopsis alba ATCC BAA-2165

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: B005_RS09115
• Protein ID: WP_036568559.1
• Coordinates: 2091008..2091388 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: J7L6B0
• Locus tag: B005_RS09120
• Protein ID: WP_014908786.1
• Coordinates: 2091385..2091711 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B005_RS09085	2086536..2087036	+	501	WP_036568550.1	tRNA adenosine deaminase-associated protein	-
B005_RS09090	2087078..2087566	+	489	WP_014910168.1	tRNA adenosine deaminase-associated protein	-
B005_RS09095	2087616..2088068	+	453	WP_014910788.1	nucleoside deaminase	-
B005_RS09105	2088203..2088757	-	555	WP_014909631.1	PadR family transcriptional regulator	-
B005_RS09110	2088822..2090837	-	2016	WP_014910775.1	NADPH-dependent 2,4-dienoyl-CoA reductase	-
B005_RS09115	2091008..2091388	+	381	WP_036568559.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B005_RS09120	2091385..2091711	+	327	WP_014908786.1	XRE family transcriptional regulator	Antitoxin
B005_RS09125	2091814..2093553	+	1740	WP_014909958.1	pyruvate dehydrogenase	-
B005_RS09135	2094038..2096200	+	2163	WP_014910329.1	DNA polymerase III subunit gamma and tau	-
B005_RS09140	2096420..2096614	+	195	WP_014909422.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-113)

Antitoxin

• HigA2-like, helix-turn-helix domain (36-98)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 14363.44 Da
• Isoelectric Point: 6.7284

>T28218 WP_036568559.1 NC_018524:2091008-2091388 [Nocardiopsis alba ATCC BAA-2165]
MTVSWNVILLDEVHDWLMILAKEDPRTADGVVAAIDTLAEVGPTLGRPFVDVINHSRIHNLKELRPRSTGNAVVRVLFVF
DPDRQAVLLVAGDKTGRWKQWYDRNIPLAEIRYQRWLAGGYSEERG

Nucleotide

• Length: 381 bp

>T28218 NC_018524:2091008-2091388 [Nocardiopsis alba ATCC BAA-2165]
ATGACTGTGTCATGGAACGTGATTCTGCTTGACGAGGTGCACGACTGGCTCATGATTCTGGCCAAGGAGGATCCGAGAAC
GGCCGATGGCGTCGTCGCGGCGATCGACACGTTGGCGGAGGTGGGGCCGACGCTCGGCCGCCCCTTCGTCGACGTCATCA
ATCACTCTCGAATCCACAACCTGAAGGAGCTGCGCCCCCGCTCCACCGGGAACGCGGTGGTTCGGGTGTTGTTCGTCTTC
GATCCGGACAGACAGGCCGTCCTGTTGGTCGCGGGGGACAAGACGGGGCGTTGGAAGCAGTGGTACGACAGGAACATCCC
TCTGGCGGAGATCCGTTATCAGAGGTGGTTGGCCGGCGGCTACTCGGAAGAGAGGGGATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11969.54 Da
• Isoelectric Point: 8.6173

>AT28218 WP_014908786.1 NC_018524:2091385-2091711 [Nocardiopsis alba ATCC BAA-2165]
MSALARTWGESRAEVIAAGGLDEERITELGRRMRAAERAYRLAEIRRRHGIDQTTLAEKLGVSQSRVSRIERGEIDRSEL
ATIKSYVEALGGTVEIVARFGDEALRVG

Nucleotide

• Length: 327 bp

>AT28218 NC_018524:2091385-2091711 [Nocardiopsis alba ATCC BAA-2165]
ATGAGCGCCTTGGCGAGAACCTGGGGTGAGAGTCGTGCGGAGGTCATCGCGGCCGGTGGGCTCGATGAGGAACGCATCAC
CGAACTCGGGCGGAGGATGCGGGCGGCGGAGCGTGCCTATCGCCTGGCCGAGATCAGGCGTCGGCATGGCATCGACCAGA
CGACACTGGCGGAGAAGCTGGGGGTTTCGCAGTCGAGGGTGTCCCGTATCGAACGGGGAGAGATCGACCGTTCCGAGCTG
GCCACCATCAAGAGCTATGTCGAAGCCCTCGGTGGAACGGTGGAGATCGTGGCCCGGTTCGGGGACGAGGCGCTGCGCGT
GGGATGA

Structures

Antitoxin

• AlphaFold DB: J7L6B0