Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5961034..5961629 Replicon chromosome
Accession NZ_CP125367
Organism Pseudomonas aeruginosa strain ZY1710

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QMK41_RS27865 Protein ID WP_003113526.1
Coordinates 5961351..5961629 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QMK41_RS27860 Protein ID WP_003099268.1
Coordinates 5961034..5961339 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMK41_RS27830 (QMK41_27830) 5956080..5956514 - 435 WP_009875803.1 hypothetical protein -
QMK41_RS27835 (QMK41_27835) 5957030..5957320 - 291 WP_152959653.1 DUF5447 family protein -
QMK41_RS27840 (QMK41_27840) 5957496..5957768 - 273 WP_058175553.1 hypothetical protein -
QMK41_RS27845 (QMK41_27845) 5958215..5958550 + 336 WP_058175552.1 hypothetical protein -
QMK41_RS27850 (QMK41_27850) 5958553..5959254 - 702 WP_152959654.1 retron Ec48 family effector membrane protein -
QMK41_RS27855 (QMK41_27855) 5959241..5960416 - 1176 WP_071557852.1 reverse transcriptase family protein -
QMK41_RS27860 (QMK41_27860) 5961034..5961339 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
QMK41_RS27865 (QMK41_27865) 5961351..5961629 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMK41_RS27870 (QMK41_27870) 5961682..5961810 - 129 Protein_5511 integrase -
QMK41_RS27875 (QMK41_27875) 5961958..5964186 + 2229 WP_003099265.1 TonB-dependent receptor -
QMK41_RS27880 (QMK41_27880) 5964256..5964903 - 648 WP_003095021.1 carbonate dehydratase -
QMK41_RS27885 (QMK41_27885) 5964965..5966203 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T282145 WP_003113526.1 NZ_CP125367:c5961629-5961351 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT282145 WP_003099268.1 NZ_CP125367:c5961339-5961034 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References