282138

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5961430..5962025 Replicon chromosome
Accession NZ_CP125365
Organism Pseudomonas aeruginosa strain ZY36

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QMK42_RS27865 Protein ID WP_003113526.1
Coordinates 5961747..5962025 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QMK42_RS27860 Protein ID WP_003099268.1
Coordinates 5961430..5961735 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMK42_RS27830 (QMK42_27830) 5956476..5956910 - 435 WP_009875803.1 hypothetical protein -
QMK42_RS27835 (QMK42_27835) 5957426..5957716 - 291 WP_152959653.1 DUF5447 family protein -
QMK42_RS27840 (QMK42_27840) 5957892..5958164 - 273 WP_058175553.1 hypothetical protein -
QMK42_RS27845 (QMK42_27845) 5958611..5958946 + 336 WP_058175552.1 hypothetical protein -
QMK42_RS27850 (QMK42_27850) 5958949..5959650 - 702 WP_152959654.1 retron Ec48 family effector membrane protein -
QMK42_RS27855 (QMK42_27855) 5959637..5960812 - 1176 WP_071557852.1 reverse transcriptase family protein -
QMK42_RS27860 (QMK42_27860) 5961430..5961735 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
QMK42_RS27865 (QMK42_27865) 5961747..5962025 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMK42_RS27870 (QMK42_27870) 5962078..5962206 - 129 Protein_5511 integrase -
QMK42_RS27875 (QMK42_27875) 5962354..5964582 + 2229 WP_003099265.1 TonB-dependent receptor -
QMK42_RS27880 (QMK42_27880) 5964652..5965299 - 648 WP_003095021.1 carbonate dehydratase -
QMK42_RS27885 (QMK42_27885) 5965361..5966599 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T282138 WP_003113526.1 NZ_CP125365:c5962025-5961747 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT282138 WP_003099268.1 NZ_CP125365:c5961735-5961430 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References