Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3803556..3804250 Replicon chromosome
Accession NZ_CP125351
Organism Escherichia fergusonii strain XJ19MCE1

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag QKW25_RS18780 Protein ID WP_181665641.1
Coordinates 3803556..3803954 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag QKW25_RS18785 Protein ID WP_046080635.1
Coordinates 3803957..3804250 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW25_RS18755 (3798920) 3798920..3799378 - 459 WP_001291987.1 xanthine phosphoribosyltransferase -
QKW25_RS18760 (3799639) 3799639..3801096 + 1458 WP_001293012.1 cytosol nonspecific dipeptidase -
QKW25_RS18765 (3801153) 3801153..3801767 - 615 WP_196082032.1 peptide chain release factor H -
QKW25_RS18770 (3801764) 3801764..3802903 - 1140 WP_196082033.1 RNA ligase RtcB family protein -
QKW25_RS18775 (3803094) 3803094..3803546 - 453 WP_196082034.1 GNAT family N-acetyltransferase -
QKW25_RS18780 (3803556) 3803556..3803954 - 399 WP_181665641.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
QKW25_RS18785 (3803957) 3803957..3804250 - 294 WP_046080635.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
QKW25_RS18790 (3804302) 3804302..3805357 - 1056 WP_001226156.1 DNA polymerase IV -
QKW25_RS18795 (3805428) 3805428..3806213 - 786 WP_196082035.1 putative lateral flagellar export/assembly protein LafU -
QKW25_RS18800 (3806185) 3806185..3807897 + 1713 Protein_3671 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(28-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15408.83 Da        Isoelectric Point: 9.6253

>T282096 WP_181665641.1 NZ_CP125351:c3803954-3803556 [Escherichia fergusonii]
MRVFKTKLIRLQLTAKELDALTADFISSKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQVRLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11223.72 Da        Isoelectric Point: 5.2170

>AT282096 WP_046080635.1 NZ_CP125351:c3804250-3803957 [Escherichia fergusonii]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKSIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References