Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2325648..2326210 Replicon chromosome
Accession NZ_CP125351
Organism Escherichia fergusonii strain XJ19MCE1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QKW25_RS11290 Protein ID WP_104919749.1
Coordinates 2325932..2326210 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag QKW25_RS11285 Protein ID WP_000781370.1
Coordinates 2325648..2325932 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW25_RS11270 (2321008) 2321008..2324055 + 3048 WP_141095958.1 formate dehydrogenase-N subunit alpha -
QKW25_RS11275 (2324068) 2324068..2324952 + 885 WP_001240580.1 formate dehydrogenase N subunit beta -
QKW25_RS11280 (2324945) 2324945..2325598 + 654 WP_196081602.1 formate dehydrogenase-N subunit gamma -
QKW25_RS11285 (2325648) 2325648..2325932 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
QKW25_RS11290 (2325932) 2325932..2326210 - 279 WP_104919749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QKW25_RS11295 (2326396) 2326396..2327406 - 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
QKW25_RS11300 (2327540) 2327540..2329237 - 1698 WP_000433464.1 malate dehydrogenase -
QKW25_RS11305 (2329394) 2329394..2329531 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
QKW25_RS11310 (2329633) 2329633..2329848 - 216 WP_000495766.1 biofilm-dependent modulation protein -
QKW25_RS11315 (2330191) 2330191..2330622 + 432 WP_196081603.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T282090 WP_104919749.1 NZ_CP125351:c2326210-2325932 [Escherichia fergusonii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADLDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT282090 WP_000781370.1 NZ_CP125351:c2325932-2325648 [Escherichia fergusonii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References