Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 747068..747326 Replicon chromosome
Accession NZ_CP125351
Organism Escherichia fergusonii strain XJ19MCE1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag QKW25_RS03740 Protein ID WP_000809168.1
Coordinates 747068..747220 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 747269..747326 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW25_RS03720 742133..742720 + 588 WP_002431696.1 molybdopterin adenylyltransferase -
QKW25_RS03725 742754..743320 - 567 WP_000528529.1 acetate uptake transporter -
QKW25_RS03730 743828..745744 + 1917 WP_000516135.1 molecular chaperone DnaK -
QKW25_RS03735 745833..746963 + 1131 WP_001118464.1 molecular chaperone DnaJ -
QKW25_RS03740 747068..747220 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 747269..747326 + 58 - - Antitoxin
QKW25_RS03745 747761..748927 + 1167 WP_000681374.1 Na+/H+ antiporter NhaA -
QKW25_RS03750 748995..749894 + 900 WP_000019049.1 transcriptional activator NhaR -
QKW25_RS03755 749990..750253 - 264 WP_001274021.1 30S ribosomal protein S20 -
QKW25_RS03760 750356..750574 + 219 WP_196081237.1 DUF2575 domain-containing protein -
QKW25_RS03765 750582..751523 + 942 WP_046081994.1 bifunctional riboflavin kinase/FAD synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T282083 WP_000809168.1 NZ_CP125351:c747220-747068 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT282083 NZ_CP125351:747269-747326 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References