Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 606212..607011 Replicon chromosome
Accession NZ_CP125351
Organism Escherichia fergusonii strain XJ19MCE1

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag QKW25_RS02920 Protein ID WP_196082266.1
Coordinates 606212..606676 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID B7LMV4
Locus tag QKW25_RS02925 Protein ID WP_015953962.1
Coordinates 606676..607011 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKW25_RS02890 (601214) 601214..601648 - 435 WP_196082267.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QKW25_RS02895 (601666) 601666..602544 - 879 WP_283154601.1 PTS N-acetylgalactosamine transporter subunit IID -
QKW25_RS02900 (602534) 602534..603313 - 780 WP_089559022.1 PTS N-acetylgalactosamine transporter subunit IIC -
QKW25_RS02905 (603324) 603324..603797 - 474 WP_032303829.1 PTS N-acetylgalactosamine transporter subunit IIB -
QKW25_RS02910 (603820) 603820..605100 - 1281 WP_180491940.1 tagatose-bisphosphate aldolase subunit KbaZ -
QKW25_RS02915 (605348) 605348..606157 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QKW25_RS02920 (606212) 606212..606676 - 465 WP_196082266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QKW25_RS02925 (606676) 606676..607011 - 336 WP_015953962.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QKW25_RS02930 (607160) 607160..608731 - 1572 WP_148047939.1 galactarate dehydratase -
QKW25_RS02935 (609202) 609202..609972 + 771 WP_148047940.1 2-dehydro-3-deoxyglucarate aldolase -
QKW25_RS02940 (609997) 609997..610887 + 891 WP_000178100.1 2-hydroxy-3-oxopropionate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17832.31 Da        Isoelectric Point: 9.6924

>T282082 WP_196082266.1 NZ_CP125351:c606676-606212 [Escherichia fergusonii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFIKMLKRGHPPADWETLTRETEEAH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12281.89 Da        Isoelectric Point: 4.4128

>AT282082 WP_015953962.1 NZ_CP125351:c607011-606676 [Escherichia fergusonii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDPTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B7LMV4

References