282067

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 743789..744564 Replicon chromosome
Accession NZ_CP125349
Organism Klebsiella pneumoniae strain WYKP594

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QJR22_RS05080 Protein ID WP_004150910.1
Coordinates 744079..744564 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QJR22_RS05075 Protein ID WP_004150912.1
Coordinates 743789..744082 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR22_RS05055 (QJR22_05060) 738997..739599 - 603 WP_062954968.1 short chain dehydrogenase -
QJR22_RS05060 (QJR22_05065) 739697..740608 + 912 WP_004188550.1 LysR family transcriptional regulator -
QJR22_RS05065 (QJR22_05070) 740609..741757 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QJR22_RS05070 (QJR22_05075) 741768..743144 - 1377 WP_004217775.1 cystathionine beta-synthase -
QJR22_RS05075 (QJR22_05080) 743789..744082 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QJR22_RS05080 (QJR22_05085) 744079..744564 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QJR22_RS05085 (QJR22_05090) 745268..745861 + 594 WP_004188553.1 hypothetical protein -
QJR22_RS05090 (QJR22_05095) 745958..746174 + 217 Protein_731 transposase -
QJR22_RS05095 (QJR22_05100) 746780..747652 + 873 WP_004188557.1 ParA family protein -
QJR22_RS05100 (QJR22_05105) 747652..748035 + 384 WP_004150906.1 hypothetical protein -
QJR22_RS05105 (QJR22_05110) 748028..749395 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 745958..746110 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T282067 WP_004150910.1 NZ_CP125349:744079-744564 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT282067 WP_004150912.1 NZ_CP125349:743789-744082 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References