Detailed information of TA system TA282060

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 41470..41896
• Replicon: plasmid pWYKP594-4
• Accession: NZ_CP125346
• Organism: Klebsiella pneumoniae strain WYKP594

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QJR22_RS00340
• Protein ID: WP_001372321.1
• Coordinates: 41470..41595 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	41672..41896 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJR22_RS00310 (37331)	37331..38583	+	1253	Protein_51	four-carbon acid sugar kinase family protein	-
QJR22_RS00315 (38576)	38576..38899	+	324	Protein_52	class II aldolase/adducin family protein	-
QJR22_RS00320 (38953)	38953..39657	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
QJR22_RS00325 (39721)	39721..40005	-	285	Protein_54	PAS domain-containing protein	-
QJR22_RS00330 (40071)	40071..40775	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
QJR22_RS00335 (40855)	40855..41151	+	297	Protein_56	hypothetical protein	-
QJR22_RS00340 (41470)	41470..41595	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
QJR22_RS00345 (41537)	41537..41686	-	150	Protein_58	plasmid maintenance protein Mok	-
- (41672)	41672..41896	-	225	NuclAT_0	-	Antitoxin
- (41672)	41672..41896	-	225	NuclAT_0	-	Antitoxin
- (41672)	41672..41896	-	225	NuclAT_0	-	Antitoxin
- (41672)	41672..41896	-	225	NuclAT_0	-	Antitoxin
QJR22_RS00350 (41908)	41908..42627	-	720	WP_001276217.1	plasmid SOS inhibition protein A	-
QJR22_RS00355 (42624)	42624..43058	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
QJR22_RS00360 (43127)	43127..45150	-	2024	Protein_61	ParB/RepB/Spo0J family partition protein	-
QJR22_RS00365 (45211)	45211..45444	-	234	WP_000006003.1	DUF905 family protein	-
QJR22_RS00370 (45502)	45502..46029	-	528	WP_000290834.1	single-stranded DNA-binding protein	-
QJR22_RS00375 (46331)	46331..46786	+	456	Protein_64	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	rmtB / blaTEM-1B / blaSHV-12	-	1..50524	50524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T282060 WP_001372321.1 NZ_CP125346:c41595-41470 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT282060 NZ_CP125346:c41896-41672 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin