Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 743821..744596 Replicon chromosome
Accession NZ_CP125343
Organism Klebsiella pneumoniae strain WYKP589

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QJR23_RS05070 Protein ID WP_004150910.1
Coordinates 744111..744596 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QJR23_RS05065 Protein ID WP_004150912.1
Coordinates 743821..744114 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR23_RS05045 (QJR23_05045) 739029..739631 - 603 WP_062954968.1 short chain dehydrogenase -
QJR23_RS05050 (QJR23_05050) 739729..740640 + 912 WP_004188550.1 LysR family transcriptional regulator -
QJR23_RS05055 (QJR23_05055) 740641..741789 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QJR23_RS05060 (QJR23_05060) 741800..743176 - 1377 WP_004217775.1 cystathionine beta-synthase -
QJR23_RS05065 (QJR23_05065) 743821..744114 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QJR23_RS05070 (QJR23_05070) 744111..744596 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QJR23_RS05075 (QJR23_05075) 745300..745893 + 594 WP_004188553.1 hypothetical protein -
QJR23_RS05080 (QJR23_05080) 745990..746206 + 217 Protein_733 transposase -
QJR23_RS05085 (QJR23_05085) 746812..747684 + 873 WP_004188557.1 ParA family protein -
QJR23_RS05090 (QJR23_05090) 747684..748067 + 384 WP_004150906.1 hypothetical protein -
QJR23_RS05095 (QJR23_05095) 748060..749427 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 745990..746142 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T282040 WP_004150910.1 NZ_CP125343:744111-744596 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT282040 WP_004150912.1 NZ_CP125343:743821-744114 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References