Detailed information of TA system TA282030

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 22746..23172
• Replicon: plasmid pWYKP589-2
• Accession: NZ_CP125342
• Organism: Klebsiella pneumoniae strain WYKP589

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: QJR23_RS00720
• Protein ID: WP_001372321.1
• Coordinates: 22746..22871 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	22948..23172 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJR23_RS00690 (18607)	18607..19859	+	1253	Protein_21	four-carbon acid sugar kinase family protein	-
QJR23_RS00695 (19852)	19852..20175	+	324	Protein_22	class II aldolase/adducin family protein	-
QJR23_RS00700 (20229)	20229..20933	-	705	WP_001067855.1	IS6-like element IS26 family transposase	-
QJR23_RS00705 (20997)	20997..21281	-	285	Protein_24	PAS domain-containing protein	-
QJR23_RS00710 (21347)	21347..22051	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-
QJR23_RS00715 (22131)	22131..22427	+	297	Protein_26	hypothetical protein	-
QJR23_RS00720 (22746)	22746..22871	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
QJR23_RS00725 (22813)	22813..22962	-	150	Protein_28	plasmid maintenance protein Mok	-
- (22948)	22948..23172	-	225	NuclAT_0	-	Antitoxin
- (22948)	22948..23172	-	225	NuclAT_0	-	Antitoxin
- (22948)	22948..23172	-	225	NuclAT_0	-	Antitoxin
- (22948)	22948..23172	-	225	NuclAT_0	-	Antitoxin
QJR23_RS00730 (23184)	23184..23903	-	720	WP_001276217.1	plasmid SOS inhibition protein A	-
QJR23_RS00735 (23900)	23900..24334	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
QJR23_RS00740 (24403)	24403..26426	-	2024	Protein_31	ParB/RepB/Spo0J family partition protein	-
QJR23_RS00745 (26487)	26487..26720	-	234	WP_000006003.1	DUF905 family protein	-
QJR23_RS00750 (26778)	26778..27305	-	528	WP_000290834.1	single-stranded DNA-binding protein	-
QJR23_RS00755 (27607)	27607..28062	+	456	Protein_34	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	blaKPC-2 / blaSHV-12 / rmtB / blaTEM-1B	-	1..110599	110599

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T282030 WP_001372321.1 NZ_CP125342:c22871-22746 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT282030 NZ_CP125342:c23172-22948 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin