Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 737085..737860 Replicon chromosome
Accession NZ_CP125334
Organism Klebsiella pneumoniae strain WYKP586

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QJR21_RS03690 Protein ID WP_004150910.1
Coordinates 737375..737860 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QJR21_RS03685 Protein ID WP_004150912.1
Coordinates 737085..737378 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJR21_RS03665 (QJR21_03665) 732293..732895 - 603 WP_062954968.1 short chain dehydrogenase -
QJR21_RS03670 (QJR21_03670) 732993..733904 + 912 WP_004188550.1 LysR family transcriptional regulator -
QJR21_RS03675 (QJR21_03675) 733905..735053 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QJR21_RS03680 (QJR21_03680) 735064..736440 - 1377 WP_004217775.1 cystathionine beta-synthase -
QJR21_RS03685 (QJR21_03685) 737085..737378 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QJR21_RS03690 (QJR21_03690) 737375..737860 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QJR21_RS03695 (QJR21_03695) 738564..739157 + 594 WP_004188553.1 hypothetical protein -
QJR21_RS03700 (QJR21_03700) 739254..739470 + 217 Protein_727 transposase -
QJR21_RS03705 (QJR21_03705) 740076..740948 + 873 WP_004188557.1 ParA family protein -
QJR21_RS03710 (QJR21_03710) 740948..741331 + 384 WP_004150906.1 hypothetical protein -
QJR21_RS03715 (QJR21_03715) 741324..742691 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 739254..739406 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T282007 WP_004150910.1 NZ_CP125334:737375-737860 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT282007 WP_004150912.1 NZ_CP125334:737085-737378 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References