Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1558871..1559383 Replicon chromosome
Accession NZ_CP125291
Organism Streptococcus pneumoniae strain 105_Kz

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag QL280_RS07810 Protein ID WP_000924721.1
Coordinates 1558871..1559125 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B7LSG7
Locus tag QL280_RS07815 Protein ID WP_000388571.1
Coordinates 1559129..1559383 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QL280_RS07795 (QL280_07795) 1555972..1556286 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
QL280_RS07800 (QL280_07800) 1556311..1556937 - 627 WP_000775037.1 guanylate kinase -
QL280_RS07805 (QL280_07805) 1557067..1558680 - 1614 WP_000404940.1 ribonuclease Y -
QL280_RS07810 (QL280_07810) 1558871..1559125 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
QL280_RS07815 (QL280_07815) 1559129..1559383 - 255 WP_000388571.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QL280_RS07820 (QL280_07820) 1559621..1560718 - 1098 WP_000156345.1 nucleotidyltransferase -
QL280_RS07825 (QL280_07825) 1560728..1561468 - 741 WP_000257066.1 class I SAM-dependent methyltransferase -
QL280_RS07830 (QL280_07830) 1561577..1561930 - 354 WP_001003001.1 ribosome silencing factor -
QL280_RS07835 (QL280_07835) 1561943..1562443 - 501 WP_000844707.1 cysteine hydrolase family protein -
QL280_RS07840 (QL280_07840) 1562444..1563037 - 594 WP_000121654.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
QL280_RS07845 (QL280_07845) 1563037..1563666 - 630 WP_000151307.1 nicotinate-nucleotide adenylyltransferase -
QL280_RS07850 (QL280_07850) 1563718..1564029 - 312 WP_000060169.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T281965 WP_000924721.1 NZ_CP125291:c1559125-1558871 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9718.05 Da        Isoelectric Point: 4.8430

>AT281965 WP_000388571.1 NZ_CP125291:c1559383-1559129 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSIQVH
VIEE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B7LSG7

References