Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5371254..5371849 Replicon chromosome
Accession NZ_CP125288
Organism Pseudomonas aeruginosa strain SF416

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag QLX61_RS24735 Protein ID WP_003117425.1
Coordinates 5371571..5371849 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QLX61_RS24730 Protein ID WP_003113527.1
Coordinates 5371254..5371559 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLX61_RS24695 (QLX61_24690) 5366393..5367241 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
QLX61_RS24705 (QLX61_24700) 5367408..5368349 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
QLX61_RS24710 (QLX61_24705) 5368466..5369080 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
QLX61_RS24715 (QLX61_24710) 5369122..5369706 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
QLX61_RS24720 (QLX61_24715) 5369747..5370847 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
QLX61_RS24730 (QLX61_24725) 5371254..5371559 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
QLX61_RS24735 (QLX61_24730) 5371571..5371849 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLX61_RS24740 (QLX61_24735) 5371902..5372030 - 129 Protein_4886 integrase -
QLX61_RS24745 (QLX61_24740) 5372178..5374406 + 2229 WP_003113525.1 TonB-dependent receptor -
QLX61_RS24750 (QLX61_24745) 5374476..5375123 - 648 WP_003095021.1 carbonate dehydratase -
QLX61_RS24755 (QLX61_24750) 5375185..5376423 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T281960 WP_003117425.1 NZ_CP125288:c5371849-5371571 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT281960 WP_003113527.1 NZ_CP125288:c5371559-5371254 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References