Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4749483..4750164 Replicon chromosome
Accession NZ_CP125288
Organism Pseudomonas aeruginosa strain SF416

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag QLX61_RS21880 Protein ID WP_003111825.1
Coordinates 4749799..4750164 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QLX61_RS21875 Protein ID WP_003145733.1
Coordinates 4749483..4749806 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLX61_RS21845 (QLX61_21840) 4745408..4746046 + 639 WP_003140882.1 hypothetical protein -
QLX61_RS21850 (QLX61_21845) 4746289..4746624 + 336 WP_003140884.1 TM2 domain-containing protein -
QLX61_RS21855 (QLX61_21850) 4746798..4747316 + 519 WP_031764395.1 PAAR domain-containing protein -
QLX61_RS21860 (QLX61_21855) 4747313..4747501 + 189 WP_023090039.1 hypothetical protein -
QLX61_RS21865 (QLX61_21860) 4747568..4748014 + 447 WP_031764396.1 VRR-NUC domain-containing protein -
QLX61_RS21870 (QLX61_21865) 4748031..4749119 + 1089 WP_031652783.1 DUF3396 domain-containing protein -
QLX61_RS21875 (QLX61_21870) 4749483..4749806 - 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
QLX61_RS21880 (QLX61_21875) 4749799..4750164 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QLX61_RS21885 (QLX61_21880) 4750428..4750667 - 240 WP_044060930.1 hypothetical protein -
QLX61_RS21890 (QLX61_21885) 4750874..4751146 + 273 WP_023090041.1 hypothetical protein -
QLX61_RS21895 (QLX61_21890) 4751177..4751602 - 426 WP_003114206.1 VOC family protein -
QLX61_RS21900 (QLX61_21895) 4751703..4752587 + 885 WP_003158600.1 LysR family transcriptional regulator -
QLX61_RS21905 (QLX61_21900) 4752560..4753513 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
QLX61_RS21910 (QLX61_21905) 4753734..4754168 + 435 WP_003116494.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T281958 WP_003111825.1 NZ_CP125288:c4750164-4749799 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT281958 WP_003145733.1 NZ_CP125288:c4749806-4749483 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure

References