Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 745142..745917 Replicon chromosome
Accession NZ_CP125088
Organism Klebsiella pneumoniae strain BAK085

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QJS47_RS03720 Protein ID WP_004150910.1
Coordinates 745432..745917 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QJS47_RS03715 Protein ID WP_004150912.1
Coordinates 745142..745435 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJS47_RS03695 (QJS47_03695) 740350..740952 - 603 WP_002916735.1 short chain dehydrogenase -
QJS47_RS03700 (QJS47_03700) 741050..741961 + 912 WP_282823277.1 LysR family transcriptional regulator -
QJS47_RS03705 (QJS47_03705) 741962..743110 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QJS47_RS03710 (QJS47_03710) 743121..744497 - 1377 WP_004217775.1 cystathionine beta-synthase -
QJS47_RS03715 (QJS47_03715) 745142..745435 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QJS47_RS03720 (QJS47_03720) 745432..745917 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QJS47_RS03725 (QJS47_03725) 746621..747214 + 594 WP_004188553.1 hypothetical protein -
QJS47_RS03730 (QJS47_03730) 747311..747527 + 217 Protein_733 transposase -
QJS47_RS03735 (QJS47_03735) 748133..749005 + 873 WP_004188557.1 ParA family protein -
QJS47_RS03740 (QJS47_03740) 749005..749388 + 384 WP_004150906.1 hypothetical protein -
QJS47_RS03745 (QJS47_03745) 749381..750748 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 747311..747463 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T281901 WP_004150910.1 NZ_CP125088:745432-745917 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT281901 WP_004150912.1 NZ_CP125088:745142-745435 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References