Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4385798..4386444 Replicon chromosome
Accession NZ_CP125083
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP1

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag QFB57_RS21865 Protein ID WP_004174016.1
Coordinates 4385798..4386145 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QFB57_RS21870 Protein ID WP_223367845.1
Coordinates 4386199..4386444 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB57_RS21855 (4381724) 4381724..4383157 + 1434 WP_032445350.1 glycogen synthase GlgA -
QFB57_RS21860 (4383175) 4383175..4385622 + 2448 WP_002920561.1 glycogen phosphorylase -
QFB57_RS21865 (4385798) 4385798..4386145 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB57_RS21870 (4386199) 4386199..4386444 + 246 WP_223367845.1 helix-turn-helix transcriptional regulator Antitoxin
QFB57_RS21875 (4386507) 4386507..4388015 - 1509 WP_019704656.1 glycerol-3-phosphate dehydrogenase -
QFB57_RS21880 (4388220) 4388220..4388549 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
QFB57_RS21885 (4388600) 4388600..4389430 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
QFB57_RS21890 (4389480) 4389480..4390238 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-66)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T281879 WP_004174016.1 NZ_CP125083:4385798-4386145 [Klebsiella pneumoniae subsp. pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8717.13 Da        Isoelectric Point: 8.6165

>AT281879 WP_223367845.1 NZ_CP125083:4386199-4386444 [Klebsiella pneumoniae subsp. pneumoniae]
IAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALGGELSINVTLPTGKKVSFN
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure

References