Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2594041..2594638 Replicon chromosome
Accession NZ_CP125083
Organism Klebsiella pneumoniae subsp. pneumoniae strain HVKP1

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag QFB57_RS13505 Protein ID WP_004142563.1
Coordinates 2594321..2594638 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag QFB57_RS13500 Protein ID WP_004142561.1
Coordinates 2594041..2594328 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QFB57_RS13470 (2590120) 2590120..2590368 + 249 WP_032445695.1 DUF1158 domain-containing protein -
QFB57_RS13475 (2590386) 2590386..2590727 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
QFB57_RS13480 (2590758) 2590758..2591873 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
QFB57_RS13485 (2592053) 2592053..2592634 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
QFB57_RS13490 (2592634) 2592634..2593003 + 370 Protein_2444 MmcQ/YjbR family DNA-binding protein -
QFB57_RS13495 (2593123) 2593123..2593776 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
QFB57_RS13500 (2594041) 2594041..2594328 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
QFB57_RS13505 (2594321) 2594321..2594638 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QFB57_RS13510 (2594823) 2594823..2595866 - 1044 WP_016946853.1 DUF2157 domain-containing protein -
QFB57_RS13515 (2596532) 2596532..2597398 - 867 Protein_2449 helix-turn-helix transcriptional regulator -
QFB57_RS13520 (2597507) 2597507..2598934 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T281871 WP_004142563.1 NZ_CP125083:c2594638-2594321 [Klebsiella pneumoniae subsp. pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT281871 WP_004142561.1 NZ_CP125083:c2594328-2594041 [Klebsiella pneumoniae subsp. pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References