Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2756538..2756801 Replicon chromosome
Accession NZ_CP124923
Organism Enterococcus faecalis strain EfsC11

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag QLQ48_RS13485 Protein ID WP_002392696.1
Coordinates 2756658..2756801 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2756538..2756725 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ48_RS13470 (2751999) 2751999..2754743 + 2745 WP_002404005.1 glycosyl hydrolase family 65 protein -
QLQ48_RS13475 (2754758) 2754758..2755408 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2755463) 2755463..2755544 + 82 NuclAT_9 - -
QLQ48_RS13480 (2755823) 2755823..2756341 + 519 WP_002354874.1 PBECR4 domain-containing protein -
- (2756538) 2756538..2756725 + 188 NuclAT_7 - Antitoxin
QLQ48_RS13485 (2756658) 2756658..2756801 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2756977) 2756977..2757121 + 145 NuclAT_11 - -
QLQ48_RS13490 (2757209) 2757209..2757334 - 126 WP_002383214.1 hypothetical protein -
QLQ48_RS13495 (2757539) 2757539..2757745 + 207 WP_224561207.1 CPBP family intramembrane metalloprotease -
QLQ48_RS13500 (2757798) 2757798..2758769 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
QLQ48_RS13505 (2758944) 2758944..2759381 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
QLQ48_RS13510 (2759514) 2759514..2760068 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T281837 WP_002392696.1 NZ_CP124923:c2756801-2756658 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 188 bp

>AT281837 NZ_CP124923:2756538-2756725 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References