Detailed information of TA system TA281830

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2683871..2684131
• Replicon: chromosome
• Accession: NZ_CP124923
• Organism: Enterococcus faecalis strain EfsC11

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: QLQ48_RS13140
• Protein ID: WP_075551663.1
• Coordinates: 2684030..2684131 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2683871..2684081 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ48_RS13115 (2679555)	2679555..2680508	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
QLQ48_RS13120 (2680547)	2680547..2681302	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
QLQ48_RS13125 (2681299)	2681299..2682264	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
QLQ48_RS13130 (2682261)	2682261..2683208	-	948	WP_002404023.1	iron chelate uptake ABC transporter family permease subunit	-
QLQ48_RS13135 (2683393)	2683393..2683845	+	453	WP_002354958.1	YueI family protein	-
- (2683871)	2683871..2684081	+	211	NuclAT_4	-	Antitoxin
- (2683908)	2683908..2684085	+	178	NuclAT_3	-	-
QLQ48_RS13140 (2684030)	2684030..2684131	-	102	WP_075551663.1	putative holin-like toxin	Toxin
- (2684305)	2684305..2684514	+	210	NuclAT_5	-	-
- (2684339)	2684339..2684518	+	180	NuclAT_2	-	-
QLQ48_RS13145 (2684463)	2684463..2684564	-	102	WP_075551663.1	putative holin-like toxin	-
QLQ48_RS13150 (2684754)	2684754..2687024	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
QLQ48_RS13155 (2687195)	2687195..2687695	+	501	WP_002354954.1	cysteine hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T281830 WP_075551663.1 NZ_CP124923:c2684131-2684030 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 211 bp

>AT281830 NZ_CP124923:2683871-2684081 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGT
TATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin