Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 596747..596979 Replicon chromosome
Accession NZ_CP124923
Organism Enterococcus faecalis strain EfsC11

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag QLQ48_RS02985 Protein ID WP_002355568.1
Coordinates 596747..596863 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 596774..596979 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ48_RS02975 (592185) 592185..594443 + 2259 WP_002363179.1 DNA helicase PcrA -
QLQ48_RS02980 (594569) 594569..596599 + 2031 WP_002384934.1 NAD-dependent DNA ligase LigA -
QLQ48_RS02985 (596747) 596747..596863 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (596774) 596774..596979 - 206 NuclAT_1 - Antitoxin
QLQ48_RS02990 (597181) 597181..597486 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
QLQ48_RS02995 (597486) 597486..598955 + 1470 WP_002358701.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
QLQ48_RS03000 (598955) 598955..600385 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
QLQ48_RS03005 (600404) 600404..601492 + 1089 WP_002403511.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T281827 WP_002355568.1 NZ_CP124923:596747-596863 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT281827 NZ_CP124923:c596979-596774 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTTTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References