Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2700746..2701008 Replicon chromosome
Accession NZ_CP124921
Organism Enterococcus faecalis strain EfsC12

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag QLQ56_RS12950 Protein ID WP_002392696.1
Coordinates 2700865..2701008 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2700746..2700932 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ56_RS12935 (2696111) 2696111..2696824 - 714 WP_002367455.1 trehalose operon repressor -
QLQ56_RS12940 (2697086) 2697086..2699830 + 2745 WP_047648974.1 glycosyl hydrolase family 65 protein -
QLQ56_RS12945 (2699845) 2699845..2700495 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2700550) 2700550..2700690 + 141 NuclAT_10 - -
- (2700746) 2700746..2700891 + 146 NuclAT_12 - -
- (2700746) 2700746..2700932 + 187 NuclAT_9 - Antitoxin
QLQ56_RS12950 (2700865) 2700865..2701008 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2701121) 2701121..2701266 + 146 NuclAT_13 - -
- (2701109) 2701109..2701307 + 199 NuclAT_8 - -
QLQ56_RS12955 (2701240) 2701240..2701383 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
QLQ56_RS12960 (2701615) 2701615..2702586 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
QLQ56_RS12965 (2702761) 2702761..2703198 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
QLQ56_RS12970 (2703331) 2703331..2703885 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T281812 WP_002392696.1 NZ_CP124921:c2701008-2700865 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 187 bp

>AT281812 NZ_CP124921:2700746-2700932 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References