Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 585384..585616 Replicon chromosome
Accession NZ_CP124921
Organism Enterococcus faecalis strain EfsC12

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag QLQ56_RS02835 Protein ID WP_002355568.1
Coordinates 585384..585500 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 585411..585616 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ56_RS02825 (580822) 580822..583080 + 2259 WP_002363179.1 DNA helicase PcrA -
QLQ56_RS02830 (583206) 583206..585236 + 2031 WP_010710796.1 NAD-dependent DNA ligase LigA -
QLQ56_RS02835 (585384) 585384..585500 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (585411) 585411..585616 - 206 NuclAT_3 - Antitoxin
QLQ56_RS02840 (585818) 585818..586123 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
QLQ56_RS02845 (586123) 586123..587592 + 1470 WP_033593283.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
QLQ56_RS02850 (587592) 587592..589022 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
QLQ56_RS02855 (589041) 589041..590129 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T281800 WP_002355568.1 NZ_CP124921:585384-585500 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT281800 NZ_CP124921:c585616-585411 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References