Detailed information of TA system TA028180

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2113897..2114552
• Replicon: chromosome
• Accession: NC_018518
• Organism: Bordetella pertussis 18323

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: BN118_RS09920
• Protein ID: WP_047122780.1
• Coordinates: 2114301..2114552 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: BN118_RS09915
• Protein ID: WP_003809516.1
• Coordinates: 2113897..2114298 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN118_RS09890	2109080..2110102	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
BN118_RS09895	2110239..2111276	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
BN118_RS09900	2111296..2112486	-	1191	WP_014905781.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BN118_RS09905	2112489..2113004	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BN118_RS09910	2113154..2113633	-	480	WP_010930405.1	disulfide bond formation protein B	-
BN118_RS19510	2113641..2113877	-	237	WP_010930404.1	membrane protein	-
BN118_RS09915	2113897..2114298	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BN118_RS09920	2114301..2114552	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BN118_RS09925	2114607..2115488	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
BN118_RS09930	2115714..2116160	+	447	WP_003819827.1	GFA family protein	-
BN118_RS09935	2116245..2117309	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
BN118_RS09940	2117446..2118027	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
BN118_RS09945	2118262..2119392	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T28180 WP_047122780.1 NC_018518:c2114552-2114301 [Bordetella pertussis 18323]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T28180 NC_018518:c2114552-2114301 [Bordetella pertussis 18323]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT28180 WP_003809516.1 NC_018518:c2114298-2113897 [Bordetella pertussis 18323]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT28180 NC_018518:c2114298-2113897 [Bordetella pertussis 18323]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6