Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2807459..2807795 Replicon chromosome
Accession NZ_CP124918
Organism Enterococcus faecalis strain EfsC9

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag QLQ61_RS13860 Protein ID WP_002381035.1
Coordinates 2807459..2807602 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2807746..2807795 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ61_RS13840 (2803560) 2803560..2804189 - 630 WP_002354763.1 lytic polysaccharide monooxygenase -
QLQ61_RS13845 (2804882) 2804882..2806498 + 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
QLQ61_RS13850 (2806828) 2806828..2806971 + 144 WP_002392818.1 type I toxin-antitoxin system toxin PepG1 -
- (2806904) 2806904..2807088 - 185 NuclAT_6 - -
- (2806945) 2806945..2807088 - 144 NuclAT_10 - -
QLQ61_RS13855 (2807090) 2807090..2807230 + 141 WP_073340360.1 putative holin-like toxin -
- (2807163) 2807163..2807361 - 199 NuclAT_4 - -
QLQ61_RS13860 (2807459) 2807459..2807602 + 144 WP_002381035.1 putative holin-like toxin Toxin
- (2807746) 2807746..2807795 + 50 NuclAT_11 - Antitoxin
- (2807534) 2807534..2807796 - 263 NuclAT_8 - -
QLQ61_RS13865 (2807797) 2807797..2812488 - 4692 WP_282874514.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T281789 WP_002381035.1 NZ_CP124918:2807459-2807602 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 50 bp

>AT281789 NZ_CP124918:2807746-2807795 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References