Detailed information of TA system TA281787

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2807459..2807796
• Replicon: chromosome
• Accession: NZ_CP124918
• Organism: Enterococcus faecalis strain EfsC9

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: QLQ61_RS13860
• Protein ID: WP_002381035.1
• Coordinates: 2807459..2807602 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2807534..2807796 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ61_RS13840 (2803560)	2803560..2804189	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
QLQ61_RS13845 (2804882)	2804882..2806498	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
QLQ61_RS13850 (2806828)	2806828..2806971	+	144	WP_002392818.1	type I toxin-antitoxin system toxin PepG1	-
- (2806904)	2806904..2807088	-	185	NuclAT_6	-	-
- (2806945)	2806945..2807088	-	144	NuclAT_10	-	-
QLQ61_RS13855 (2807090)	2807090..2807230	+	141	WP_073340360.1	putative holin-like toxin	-
- (2807163)	2807163..2807361	-	199	NuclAT_4	-	-
QLQ61_RS13860 (2807459)	2807459..2807602	+	144	WP_002381035.1	putative holin-like toxin	Toxin
- (2807746)	2807746..2807795	+	50	NuclAT_11	-	-
- (2807534)	2807534..2807796	-	263	NuclAT_8	-	Antitoxin
QLQ61_RS13865 (2807797)	2807797..2812488	-	4692	WP_282874514.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T281787 WP_002381035.1 NZ_CP124918:2807459-2807602 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT281787 NZ_CP124918:c2807796-2807534 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin