Detailed information of TA system TA281780

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2806904..2807230
• Replicon: chromosome
• Accession: NZ_CP124918
• Organism: Enterococcus faecalis strain EfsC9

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: QLQ61_RS13855
• Protein ID: WP_073340360.1
• Coordinates: 2807090..2807230 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2806904..2807088 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ61_RS13830 (2801950)	2801950..2802165	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
QLQ61_RS13835 (2802304)	2802304..2803296	+	993	WP_002354765.1	biotin--[acetyl-CoA-carboxylase] ligase	-
QLQ61_RS13840 (2803560)	2803560..2804189	-	630	WP_002354763.1	lytic polysaccharide monooxygenase	-
QLQ61_RS13845 (2804882)	2804882..2806498	+	1617	WP_002381036.1	phosphatase PAP2/LCP family protein	-
QLQ61_RS13850 (2806828)	2806828..2806971	+	144	WP_002392818.1	type I toxin-antitoxin system toxin PepG1	-
- (2806904)	2806904..2807088	-	185	NuclAT_6	-	Antitoxin
- (2806945)	2806945..2807088	-	144	NuclAT_10	-	-
QLQ61_RS13855 (2807090)	2807090..2807230	+	141	WP_073340360.1	putative holin-like toxin	Toxin
- (2807163)	2807163..2807361	-	199	NuclAT_4	-	-
QLQ61_RS13860 (2807459)	2807459..2807602	+	144	WP_002381035.1	putative holin-like toxin	-
- (2807746)	2807746..2807795	+	50	NuclAT_11	-	-
- (2807534)	2807534..2807796	-	263	NuclAT_8	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T281780 WP_073340360.1 NZ_CP124918:2807090-2807230 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T281780 NZ_CP124918:2807090-2807230 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT281780 NZ_CP124918:c2807088-2806904 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin