Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2722160..2722623 Replicon chromosome
Accession NZ_CP124918
Organism Enterococcus faecalis strain EfsC9

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag QLQ61_RS13470 Protein ID WP_002392696.1
Coordinates 2722160..2722303 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2722479..2722623 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ61_RS13455 (2717406) 2717406..2718119 - 714 WP_002381063.1 trehalose operon repressor -
QLQ61_RS13460 (2718381) 2718381..2721125 + 2745 WP_002398920.1 glycosyl hydrolase family 65 protein -
QLQ61_RS13465 (2721140) 2721140..2721790 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2722040) 2722040..2722227 + 188 NuclAT_5 - -
QLQ61_RS13470 (2722160) 2722160..2722303 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2722479) 2722479..2722623 + 145 NuclAT_9 - Antitoxin
QLQ61_RS13475 (2723377) 2723377..2723652 + 276 WP_224805966.1 CPBP family intramembrane metalloprotease -
QLQ61_RS13480 (2723705) 2723705..2724676 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
QLQ61_RS13485 (2724851) 2724851..2725288 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
QLQ61_RS13490 (2725421) 2725421..2725975 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T281774 WP_002392696.1 NZ_CP124918:c2722303-2722160 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 145 bp

>AT281774 NZ_CP124918:2722479-2722623 [Enterococcus faecalis]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References