Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2802922..2803258 Replicon chromosome
Accession NZ_CP124916
Organism Enterococcus faecalis strain EfsC17

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag QLQ62_RS13870 Protein ID WP_002381035.1
Coordinates 2802922..2803065 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2803209..2803258 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ62_RS13850 2798102..2798317 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ62_RS13855 2798456..2799448 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ62_RS13860 2799712..2800350 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QLQ62_RS13865 2801036..2802652 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -
QLQ62_RS13870 2802922..2803065 + 144 WP_002381035.1 putative holin-like toxin Toxin
- 2803209..2803258 + 50 - - Antitoxin
QLQ62_RS13875 2803260..2807087 - 3828 WP_010816211.1 WxL domain-containing protein -
QLQ62_RS13880 2807074..2807436 - 363 WP_002378868.1 LPXTG cell wall anchor domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T281762 WP_002381035.1 NZ_CP124916:2802922-2803065 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 50 bp

>AT281762 NZ_CP124916:2803209-2803258 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References