Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 457656..457910 Replicon chromosome
Accession NZ_CP124914
Organism Enterococcus faecalis strain EfsC8

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag QLQ37_RS02265 Protein ID WP_002355568.1
Coordinates 457656..457772 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 457755..457910 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ37_RS02255 (453094) 453094..455352 + 2259 WP_002363179.1 DNA helicase PcrA -
QLQ37_RS02260 (455478) 455478..457508 + 2031 WP_002375948.1 NAD-dependent DNA ligase LigA -
QLQ37_RS02265 (457656) 457656..457772 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (457683) 457683..457888 - 206 NuclAT_3 - -
- (457755) 457755..457890 - 136 NuclAT_9 - -
- (457755) 457755..457910 - 156 NuclAT_7 - Antitoxin
QLQ37_RS02270 (458090) 458090..458395 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
QLQ37_RS02275 (458395) 458395..459864 + 1470 WP_002419989.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
QLQ37_RS02280 (459864) 459864..461294 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
QLQ37_RS02285 (461313) 461313..462401 + 1089 WP_002383001.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T281739 WP_002355568.1 NZ_CP124914:457656-457772 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 156 bp

>AT281739 NZ_CP124914:c457910-457755 [Enterococcus faecalis]
GAAATATGTTATTATGAAAATGAAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTG
GTGGCTTACTGAGTTATTGGTTTTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References