281732

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2464938..2465170 Replicon chromosome
Accession NZ_CP124913
Organism Enterococcus faecalis strain EfsC20

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag QLQ32_RS11810 Protein ID WP_002355568.1
Coordinates 2465054..2465170 (-) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2464938..2465143 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ32_RS11790 2460425..2461513 - 1089 WP_002355572.1 diacylglycerol kinase -
QLQ32_RS11795 2461532..2462962 - 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
QLQ32_RS11800 2462962..2464431 - 1470 WP_002358701.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
QLQ32_RS11805 2464431..2464736 - 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
- 2464938..2465143 + 206 - - Antitoxin
QLQ32_RS11810 2465054..2465170 - 117 WP_002355568.1 putative holin-like toxin Toxin
QLQ32_RS11815 2465318..2467348 - 2031 WP_002384934.1 NAD-dependent DNA ligase LigA -
QLQ32_RS11820 2467474..2469732 - 2259 WP_002363179.1 DNA helicase PcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - psaA / esp / cylI / cylA / cylB / cylM / cylS / cylL / cylR1 / cylR2 2463019..2660643 197624


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T281732 WP_002355568.1 NZ_CP124913:c2465170-2465054 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT281732 NZ_CP124913:2464938-2465143 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTTTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References