Detailed information of TA system TA281718

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2884269..2884606
• Replicon: chromosome
• Accession: NZ_CP124911
• Organism: Enterococcus faecalis strain EfsC61

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A125WAU0
• Locus tag: QLQ53_RS14215
• Protein ID: WP_002391551.1
• Coordinates: 2884269..2884412 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2884344..2884606 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ53_RS14200	2879985..2880617	-	633	WP_002358972.1	RloB family protein	-
QLQ53_RS14205	2880626..2881921	-	1296	WP_010785619.1	ATP-binding protein	-
QLQ53_RS14210	2882383..2883999	+	1617	WP_002365430.1	phosphatase PAP2/LCP family protein	-
QLQ53_RS14215	2884269..2884412	+	144	WP_002391551.1	putative holin-like toxin	Toxin
-	2884344..2884606	-	263	-	-	Antitoxin
QLQ53_RS14220	2884607..2887624	-	3018	WP_010830429.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5175.17 Da
• Isoelectric Point: 8.6389

>T281718 WP_002391551.1 NZ_CP124911:2884269-2884412 [Enterococcus faecalis]
MNVSTKIYEKRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT281718 NZ_CP124911:c2884606-2884344 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A125WAU0

Antitoxin