Detailed information of TA system TA281688

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2817550..2817887
• Replicon: chromosome
• Accession: NZ_CP124908
• Organism: Enterococcus faecalis strain EfsC33

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: QLQ33_RS13640
• Protein ID: WP_002396786.1
• Coordinates: 2817550..2817693 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2817625..2817887 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ33_RS13620 (2812667)	2812667..2812882	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
QLQ33_RS13625 (2813021)	2813021..2814013	+	993	WP_023894581.1	biotin--[acetyl-CoA-carboxylase] ligase	-
QLQ33_RS13630 (2814277)	2814277..2814915	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
QLQ33_RS13635 (2815601)	2815601..2817217	+	1617	WP_047648929.1	phosphatase PAP2/LCP family protein	-
QLQ33_RS13640 (2817550)	2817550..2817693	+	144	WP_002396786.1	putative holin-like toxin	Toxin
- (2817837)	2817837..2817886	+	50	NuclAT_11	-	-
- (2817625)	2817625..2817887	-	263	NuclAT_8	-	Antitoxin
QLQ33_RS13645 (2817888)	2817888..2822579	-	4692	WP_049098584.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T281688 WP_002396786.1 NZ_CP124908:2817550-2817693 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 263 bp

>AT281688 NZ_CP124908:c2817887-2817625 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin