281684

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2691684..2691958 Replicon chromosome
Accession NZ_CP124908
Organism Enterococcus faecalis strain EfsC33

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag QLQ33_RS13090 Protein ID WP_002392696.1
Coordinates 2691815..2691958 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2691684..2691882 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ33_RS13070 (2686686) 2686686..2687399 - 714 WP_002367455.1 trehalose operon repressor -
QLQ33_RS13075 (2687661) 2687661..2690405 + 2745 WP_047648974.1 glycosyl hydrolase family 65 protein -
QLQ33_RS13080 (2690420) 2690420..2691070 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2691125) 2691125..2691265 + 141 NuclAT_7 - -
- (2691321) 2691321..2691466 + 146 NuclAT_9 - -
- (2691321) 2691321..2691507 + 187 NuclAT_6 - -
QLQ33_RS13085 (2691440) 2691440..2691583 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
- (2691696) 2691696..2691841 + 146 NuclAT_10 - -
- (2691684) 2691684..2691882 + 199 NuclAT_5 - Antitoxin
QLQ33_RS13090 (2691815) 2691815..2691958 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
QLQ33_RS13095 (2692190) 2692190..2693161 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
QLQ33_RS13100 (2693336) 2693336..2693773 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
QLQ33_RS13105 (2693906) 2693906..2694460 - 555 WP_002354869.1 Maf family protein -
QLQ33_RS13110 (2694485) 2694485..2696617 - 2133 WP_002378991.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T281684 WP_002392696.1 NZ_CP124908:c2691958-2691815 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT281684 NZ_CP124908:2691684-2691882 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References