Detailed information of TA system TA281659

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2560183..2560446
• Replicon: chromosome
• Accession: NZ_CP124906
• Organism: Enterococcus faecalis strain EfsC49

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: QLQ59_RS12345
• Protein ID: WP_002392696.1
• Coordinates: 2560303..2560446 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2560183..2560370 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ59_RS12330	2555644..2558388	+	2745	WP_002392693.1	glycosyl hydrolase family 65 protein	-
QLQ59_RS12335	2558403..2559053	+	651	WP_002354875.1	beta-phosphoglucomutase	-
QLQ59_RS12340	2559468..2559986	+	519	WP_002354874.1	PBECR4 domain-containing protein	-
-	2560183..2560370	+	188	-	-	Antitoxin
QLQ59_RS12345	2560303..2560446	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
QLQ59_RS12350	2560854..2560979	-	126	WP_002383214.1	hypothetical protein	-
QLQ59_RS12355	2561184..2561390	+	207	WP_224561207.1	CPBP family intramembrane metalloprotease	-
QLQ59_RS12360	2561443..2562414	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
QLQ59_RS12365	2562589..2563026	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
QLQ59_RS12370	2563159..2563713	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T281659 WP_002392696.1 NZ_CP124906:c2560446-2560303 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 188 bp

>AT281659 NZ_CP124906:2560183-2560370 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACTTTTT
GAATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGT
GCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin