Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2740161..2740460 Replicon chromosome
Accession NZ_CP124901
Organism Enterococcus faecalis strain EfsC94

Toxin (Protein)


Gene name txpA Uniprot ID A0A8B3RWV6
Locus tag QLQ35_RS13350 Protein ID WP_002424907.1
Coordinates 2740161..2740343 (+) Length 61 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2740276..2740460 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ35_RS13330 (2735377) 2735377..2735592 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QLQ35_RS13335 (2735731) 2735731..2736723 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ35_RS13340 (2736987) 2736987..2737625 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QLQ35_RS13345 (2738313) 2738313..2739929 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
QLQ35_RS13350 (2740161) 2740161..2740343 + 183 WP_002424907.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2740276) 2740276..2740460 - 185 NuclAT_7 - Antitoxin
- (2740317) 2740317..2740460 - 144 NuclAT_9 - -
QLQ35_RS13355 (2740462) 2740462..2740602 + 141 WP_073340360.1 putative holin-like toxin -
- (2740535) 2740535..2740736 - 202 NuclAT_6 - -
QLQ35_RS13360 (2740830) 2740830..2740973 + 144 WP_002396786.1 putative holin-like toxin -
- (2741117) 2741117..2741166 + 50 NuclAT_10 - -
- (2740905) 2740905..2741167 - 263 NuclAT_8 - -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(27-60)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6952.45 Da        Isoelectric Point: 11.0738

>T281624 WP_002424907.1 NZ_CP124901:2740161-2740343 [Enterococcus faecalis]
MAVAIQSEREVMRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 183 bp

Antitoxin


Download         Length: 185 bp

>AT281624 NZ_CP124901:c2740460-2740276 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3RWV6

Antitoxin

Download structure file

References