Detailed information of TA system TA281617

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2597684..2597904
• Replicon: chromosome
• Accession: NZ_CP124901
• Organism: Enterococcus faecalis strain EfsC94

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: QLQ35_RS12675
• Protein ID: WP_021164441.1
• Coordinates: 2597803..2597904 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2597684..2597858 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ35_RS12650 (2593331)	2593331..2594284	-	954	WP_010830689.1	siderophore ABC transporter substrate-binding protein	-
QLQ35_RS12655 (2594323)	2594323..2595078	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
QLQ35_RS12660 (2595075)	2595075..2596040	-	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
QLQ35_RS12665 (2596037)	2596037..2596984	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
QLQ35_RS12670 (2597169)	2597169..2597621	+	453	WP_002378959.1	YueI family protein	-
- (2597647)	2597647..2597854	+	208	NuclAT_1	-	-
- (2597684)	2597684..2597858	+	175	NuclAT_5	-	Antitoxin
QLQ35_RS12675 (2597803)	2597803..2597904	-	102	WP_021164441.1	putative holin-like toxin	Toxin
- (2598079)	2598079..2598283	+	205	NuclAT_2	-	-
- (2598113)	2598113..2598300	+	188	NuclAT_4	-	-
QLQ35_RS12680 (2598237)	2598237..2598338	-	102	WP_021164442.1	putative holin-like toxin	-
QLQ35_RS12685 (2598529)	2598529..2600799	-	2271	WP_282860979.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
QLQ35_RS12690 (2600970)	2600970..2601471	+	502	Protein_2473	cysteine hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T281617 WP_021164441.1 NZ_CP124901:c2597904-2597803 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 175 bp

>AT281617 NZ_CP124901:2597684-2597858 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Structures

Antitoxin