Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 256188..256525 Replicon chromosome
Accession NZ_CP124898
Organism Enterococcus faecalis strain EfsC109-2

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag QLQ52_RS01205 Protein ID WP_002396786.1
Coordinates 256382..256525 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 256188..256450 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ52_RS01200 251496..256187 + 4692 WP_002378865.1 WxL domain-containing protein -
- 256188..256450 + 263 - - Antitoxin
QLQ52_RS01205 256382..256525 - 144 WP_002396786.1 putative holin-like toxin Toxin
QLQ52_RS01210 256857..258473 - 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -
QLQ52_RS01215 259158..259796 + 639 WP_002378863.1 lytic polysaccharide monooxygenase -
QLQ52_RS01220 259963..260955 - 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
QLQ52_RS01225 261094..261309 + 216 WP_002354768.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T281573 WP_002396786.1 NZ_CP124898:c256525-256382 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT281573 NZ_CP124898:256188-256450 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References