Detailed information of TA system TA281560

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 2727350..2727612
• Replicon: chromosome
• Accession: NZ_CP124894
• Organism: Enterococcus faecalis strain EfsC116

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: QLQ63_RS13375
• Protein ID: WP_002392696.1
• Coordinates: 2727469..2727612 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	2727350..2727495 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ63_RS13360 (2723315)	2723315..2726059	+	2745	WP_047648974.1	glycosyl hydrolase family 65 protein	-
QLQ63_RS13365 (2726074)	2726074..2726724	+	651	WP_002354875.1	beta-phosphoglucomutase	-
- (2726779)	2726779..2726919	+	141	NuclAT_7	-	-
- (2726975)	2726975..2727120	+	146	NuclAT_9	-	-
- (2726975)	2726975..2727161	+	187	NuclAT_6	-	-
QLQ63_RS13370 (2727094)	2727094..2727237	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	-
- (2727350)	2727350..2727495	+	146	NuclAT_10	-	Antitoxin
- (2727338)	2727338..2727536	+	199	NuclAT_5	-	-
QLQ63_RS13375 (2727469)	2727469..2727612	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
QLQ63_RS13380 (2727844)	2727844..2728815	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
QLQ63_RS13385 (2728990)	2728990..2729427	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
QLQ63_RS13390 (2729560)	2729560..2730114	-	555	WP_002354869.1	Maf family protein	-
QLQ63_RS13395 (2730139)	2730139..2732271	-	2133	WP_002378991.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T281560 WP_002392696.1 NZ_CP124894:c2727612-2727469 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 146 bp

>AT281560 NZ_CP124894:2727350-2727495 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin