281558

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2727338..2727612 Replicon chromosome
Accession NZ_CP124894
Organism Enterococcus faecalis strain EfsC116

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag QLQ63_RS13375 Protein ID WP_002392696.1
Coordinates 2727469..2727612 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2727338..2727536 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ63_RS13355 (2722340) 2722340..2723053 - 714 WP_002367455.1 trehalose operon repressor -
QLQ63_RS13360 (2723315) 2723315..2726059 + 2745 WP_047648974.1 glycosyl hydrolase family 65 protein -
QLQ63_RS13365 (2726074) 2726074..2726724 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2726779) 2726779..2726919 + 141 NuclAT_7 - -
- (2726975) 2726975..2727120 + 146 NuclAT_9 - -
- (2726975) 2726975..2727161 + 187 NuclAT_6 - -
QLQ63_RS13370 (2727094) 2727094..2727237 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
- (2727350) 2727350..2727495 + 146 NuclAT_10 - -
- (2727338) 2727338..2727536 + 199 NuclAT_5 - Antitoxin
QLQ63_RS13375 (2727469) 2727469..2727612 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
QLQ63_RS13380 (2727844) 2727844..2728815 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
QLQ63_RS13385 (2728990) 2728990..2729427 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
QLQ63_RS13390 (2729560) 2729560..2730114 - 555 WP_002354869.1 Maf family protein -
QLQ63_RS13395 (2730139) 2730139..2732271 - 2133 WP_002378991.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T281558 WP_002392696.1 NZ_CP124894:c2727612-2727469 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT281558 NZ_CP124894:2727338-2727536 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References