Detailed information of TA system TA281537

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2597774..2598035
• Replicon: chromosome
• Accession: NZ_CP124893
• Organism: Enterococcus faecalis strain EfsC123

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: QLQ42_RS12470
• Protein ID: WP_224561205.1
• Coordinates: 2597934..2598035 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2597774..2597985 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ42_RS12445	2593458..2594411	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
QLQ42_RS12450	2594450..2595205	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
QLQ42_RS12455	2595202..2596167	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
QLQ42_RS12460	2596164..2597111	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
QLQ42_RS12465	2597296..2597748	+	453	WP_002378807.1	YueI family protein	-
-	2597774..2597985	+	212	-	-	Antitoxin
QLQ42_RS12470	2597934..2598035	-	102	WP_224561205.1	putative holin-like toxin	Toxin
QLQ42_RS12475	2598226..2600496	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
QLQ42_RS12480	2600667..2601173	+	507	WP_002378810.1	cysteine hydrolase family protein	-
QLQ42_RS12485	2601363..2602259	+	897	WP_002365354.1	YitT family protein	-
QLQ42_RS12490	2602310..2602708	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T281537 WP_224561205.1 NZ_CP124893:c2598035-2597934 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 212 bp

>AT281537 NZ_CP124893:2597774-2597985 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGG
TTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin