Detailed information of TA system TA281525

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2629533..2629931
• Replicon: chromosome
• Accession: NZ_CP124891
• Organism: Enterococcus faecalis strain EfsC130

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: QLQ45_RS12725
• Protein ID: WP_227330998.1
• Coordinates: 2629533..2629637 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2629789..2629931 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QLQ45_RS12710 (2624845)	2624845..2625558	-	714	WP_002354877.1	trehalose operon repressor	-
QLQ45_RS12715 (2625819)	2625819..2628563	+	2745	WP_282874049.1	glycosyl hydrolase family 65 protein	-
QLQ45_RS12720 (2628578)	2628578..2629228	+	651	WP_002383215.1	beta-phosphoglucomutase	-
- (2629257)	2629257..2629371	+	115	NuclAT_10	-	-
- (2629413)	2629413..2629600	+	188	NuclAT_5	-	-
QLQ45_RS12725 (2629533)	2629533..2629637	-	105	WP_227330998.1	putative holin-like toxin	Toxin
- (2629789)	2629789..2629931	+	143	NuclAT_9	-	Antitoxin
QLQ45_RS12730 (2630019)	2630019..2630144	-	126	WP_002383214.1	hypothetical protein	-
QLQ45_RS12735 (2630428)	2630428..2630961	+	534	WP_002416003.1	CPBP family intramembrane metalloprotease	-
QLQ45_RS12740 (2631014)	2631014..2631985	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
QLQ45_RS12745 (2632160)	2632160..2632597	-	438	WP_010715474.1	peptide-methionine (R)-S-oxide reductase MsrB	-
QLQ45_RS12750 (2632730)	2632730..2633284	-	555	WP_002383211.1	nucleoside triphosphate pyrophosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3827.68 Da
• Isoelectric Point: 10.0079

>T281525 WP_227330998.1 NZ_CP124891:c2629637-2629533 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIVLIVKLLKNDNKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 143 bp

>AT281525 NZ_CP124891:2629789-2629931 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACCGATCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Antitoxin