Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 470488..470720 Replicon chromosome
Accession NZ_CP124890
Organism Enterococcus faecalis strain EfsPF2

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag QLQ38_RS02335 Protein ID WP_002355568.1
Coordinates 470488..470604 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 470515..470720 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ38_RS02325 (465926) 465926..468184 + 2259 WP_033657650.1 DNA helicase PcrA -
QLQ38_RS02330 (468310) 468310..470340 + 2031 WP_002358699.1 NAD-dependent DNA ligase LigA -
QLQ38_RS02335 (470488) 470488..470604 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (470515) 470515..470720 - 206 NuclAT_8 - Antitoxin
QLQ38_RS02340 (470922) 470922..471227 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
QLQ38_RS02345 (471227) 471227..472696 + 1470 WP_002398120.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
QLQ38_RS02350 (472696) 472696..474126 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
QLQ38_RS02355 (474145) 474145..475233 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T281500 WP_002355568.1 NZ_CP124890:470488-470604 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT281500 NZ_CP124890:c470720-470515 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGTGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGCGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References