Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 275275..275612 Replicon chromosome
Accession NZ_CP124889
Organism Enterococcus faecalis strain EfsPF5

Toxin (Protein)


Gene name txpA Uniprot ID E2Z0W4
Locus tag QLQ34_RS01305 Protein ID WP_002381035.1
Coordinates 275469..275612 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 275275..275537 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QLQ34_RS01300 270583..275274 + 4692 WP_010783624.1 WxL domain-containing protein -
- 275275..275537 + 263 - - Antitoxin
QLQ34_RS01305 275469..275612 - 144 WP_002381035.1 putative holin-like toxin Toxin
QLQ34_RS01310 275841..275981 - 141 WP_073340360.1 putative holin-like toxin -
QLQ34_RS01315 276100..276243 - 144 WP_002392818.1 type I toxin-antitoxin system toxin PepG1 -
QLQ34_RS01320 276573..278189 - 1617 WP_002381036.1 phosphatase PAP2/LCP family protein -
QLQ34_RS01325 278882..279511 + 630 WP_002354763.1 lytic polysaccharide monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5202.20 Da        Isoelectric Point: 10.0041

>T281477 WP_002381035.1 NZ_CP124889:c275612-275469 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT281477 NZ_CP124889:275275-275537 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6BWH2

Antitoxin

Download structure file

References